Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge.
نویسندگان
چکیده
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.
منابع مشابه
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ورودعنوان ژورنال:
- Infection and immunity
دوره 74 3 شماره
صفحات -
تاریخ انتشار 2006